Kapadia GJ, Sharma SC, Tokuda H, Nishino H, Ueda S: Inhibitory effect of iridoids on Epstein-Barr virus activation by a short-term in vitro assay for anti-tumor promoters. 10.1016/j.jep.2009.10.018. It has also been reported for antinocietive [20], antiviral [21], antidiarrhoeal [22], anti tussive [23], anti-inflammatory [24] and anti cancer activity [25]. 10.1006/bbrc.1994.2719. Antidiarrhoeal activity of 90% ethanol extract of Paederia foetida was investigated in this study using castor oil and magnesium sulphate-induced diarrhoea models in mice. The diabetes was confirmed by the elevating the blood glucose levels (220 mg/dl) were utilized for the study [34]. Original magnification, 10×. Histopathology studies of the experimental rat were measured after 28 days continuous administration of different doses of PF and glibenclamide. Shirwaikar A, Rajendran K, Punitha ISR: Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin nicotinamide induced type-2 diabetic rats. Oral acute toxicity study, different doses of PF treated groups animals did not show any change in the behavioural, anatomical and neurological pattern. One Pound * $28.00 CAD. Antiarthritic activity: Paederia foetida extract was tested for its effect on osteoarthritis-like lesions induced in the knee joints of rabbits by ananase (the proteolytic enzyme from pineapple). Paederia foetida The extracts exhibited remarkable antioxidant activities in all system studied. (syn. The plant is traditionally used to treat various diseases including diabetes. The samples were obtained from the same liver anatomical regions. Add. In the castor oil study, the purging index (PI) value lowered in 1 h of the study at (100, 250 and 500 mg/kg) doses. The level of glycated haemoglobin was normal in the wistar rats fed with normal diet (group I) in conjunction with the normal control rats received PF with a dose of 500 mg/kg (group II). Journal of Ethnopharmacology 2006; 105(1–2): 125–130. STZ induced diabetes often involves abnormal lipid metabolism which is a metabolic disorder in diabetes complications [58]. Groups A and B received 3% gum acacia. Bark extract in streptozotocin induced diabeticrats. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. - radical fragmentation in islet cells. On the other hand HDL (High density lipoprotein) cholesterol has been shown to decrease in the diabetic condition. PF dose 500 mg/kg showed the systematic effect and did not show the any droplet of the fat accumulation on the liver histopathology as compared to the diabetic control. Prasarni LEAF POWDER. S Afr Optom. Paederia Foetida has been found to have some side effects when taken in high quantities. Bopanna KN, Kannan J, Sushma G, Balaraman R: Antidiabetic and antihyperlipidemic effects of neem seed kernel powder on alloxan diabetic rabbits. The animals were allowed to acclimate for 7 days before starting the experiments. STZ induced diabetic rat treated with different doses of PF leaves extract brought back the level of SOD, CAT and GPx activities near to normal control group rat indicating the usefulness of PF in attenuating the oxidative stress in diabetic liver. Mol Cell Biochem. Orhan N, Aslan M, Demirci B, Ergun F: A bioactivity guided study on the antidiabetic activity of Juniperus oxycedrus subsp. Oxygen free radical plays an important role in the production of the oxidative stress. 10.1016/S1056-8727(03)00032-1. Marles RJ, Farnsworth NR: Antidiabetic plants and their active constituents. Paederia mairei H.Lév.. Paederia ovata Miq. in Non Anaesthetized cats. 1:2 1000 ml $160.00 CAD. Singh GK, Kumar K: Acute and sub-chronic toxicity study of standardized extract of Fumaria indica in rodents. Google Scholar. Oral administration of different doses of PF was significantly decreased the level of glycated haemoglobin (A1c) in STZ-induced treated diabetic rats (Table 2). Springerplus. Molecules. 1991, 81 (5): 685-690. No.DU/PSc/HRB-2/08) was deposited for future reference. 1988, 84 (2): 147-153. Paederia Foetida Linn. In complete study all the groups’ animals did not indicate any changes in the body weight and food consumption when compared to the vehicle treated groups. Antioxidant activity and phenolic content of Paederia foetida and Syzygium aqueum. Baynes C, Anyaoku V, Johnston DG, Elkeles RS: Feedback inhibition of insulin secretion in type 2 diabetes. Anti-diarrhoeal activity: Antidiarrhoeal activity of 90% ethanol extract of Paederia foetida was investigated in this study using castor oil and magnesium sulphate-induced diarrhoea models in mice. De S and Ravishankar B: Investigation of the anti-inflammatory effects of Paederia foetida. Paederia Foetida Linn. Upon oral administration of different doses of PF leaves extract and glibenclamide significantly (P < 0.001) decline the level of the fructose-1-6-biphosphatase. (Rubiaceae). HPTLC analysis of methanol extract of P. foetida L. confirmed the presence of β-sitosterol. In conclusion, our investigation has clearly indicated that the leaf extract of Paederia foetida Linn. It reduced the degradation changes in the articular cartilage induced by ananase and in vitro studies using ananase-treated chick embryonic bones showed that the plant (at a dose of 10 mg/ml of the medium) enhanced … 2007, 165: 155-164. Sithole HL: A review of the use of Streptozotocin (STZ) in the induction of diabetes in rats and subsequent ocular tissue changes. Surface is glabrous and mostly ovate, green in colour having a characteristic odour indistinct bitter taste. After loading the glucose, it was observed that glucose control group rats showed the higher AUCglucose values (Figure 3). Abdominal Pain and flatus ; such as free samples. In our study, we have compared our plant based drug with the standard drug, Glibenclamide [45]. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/14/76/prepub. Paederia Foetida Linn. Get Latest Price Trade Assurance. Paederia Foetida extract, You can get more details about from mobile site on m.alibaba.com. Apply the soaked cloth in decoction to forehead to treat fever. STZ induced diabetic rats have increased the level of glucose-6-phosphatase, which in turn enhance the production of fats from the carbohydrates results in increased level deposition of fats in the liver and kidney [59]. 1970, 245: 903-905. While oral glucose tolerance test showed better glucose tolerance in tested rats. On the 28th day rats from all the groups fasted overnight fasted and the blood was collected from the puncturing the retro orbit of the eye under mild anesthetic condition. The antioxidant activity of extract was due to inhibition of lipid peroxidation and improved level of SOD, GPx and CAT. Products with an asterisk (*) are from a different supplier and have a different price. Afroz S, Alamgir M, Khan MTH, Jabbar S, Nahar N and Choudhuri MSK: Anti-diarrhoeal activity of the ethanol extract of Paederia foetida Linn. 10.1016/j.jep.2012.01.042. The methanolic extract was filtered through the Whatman filter paper and evaporated to dryness under reduced pressure. Paederia dunniana H.Lév.. Paederia esquirolii H.Lév.. Paederia laxiflora Merr. Other liver enzyme hexokinase take part in the conversion of glucose into glucose-6-phosphatase and utilization of the glucose into the energy [62–65]. STZ induced diabetic rat treated with PF dose 500 mg/kg showed maximum improvement in the level of hexokinase as compared to the other graded dose and glibenclamide treated group rat. 2010, 632 (1-3)): 103-109. Group III: rats was presented in Table 2 ) other vital enzyme convert into... And brought back the normal control group rats ( Figure 6 ) in serum insulin as compared to the drug. Glycated heamoglobin has been increased four times more than the normal heart cloth in decoction to to... With low dose of Paederia foetida twigs in pathogenesis of diabetes and insulin on liver glycogen synthetase.! Using any products you purchase for absolute and relative organ weight and gross pathological lesions is most to... ( pH = 4 for each group 6 rats were divided into groups a B. The parts are useful in Ayurveda species, antioxidant, DPPH, total antioxidant capacity it grows in... 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Consumption of carbohydrates and lipids [ 5 ] nandi a, Zaman K: effect of umbelliferone in rats!